Clinical Trials

CLINICAL TRIALS

We’re making microbiome history

A leader in microbiome research, Pendulum is discovering the important connections between our health and the microbiome.

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Scientific research is our foundation

Scientific Discoveries

Breakthroughs are put to the test with clinical trials

Human Advancement

Through rigorous trial protocols, our knowledge grows

Groundbreaking Innovation

Results help us create effective products that improve your health

Participate in breakthrough research

Clinical trials are integral to developing new approaches to medicine. Through collaboration with leading academic research institutions, top investigators, and passionate human beings all over the world, we grow our understanding of the microbiome and unravel its connection to your health — together.

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All Trials

GLP-1 Probiotic

A Two-Phase Study on the Safety and Tolerance of a Novel Probiotic in Healthy Adults: Open-Label and Double-Blind, Placebo-Controlled Study

Duration:2 months

Eligibility:Healthy adults, aged between 18-65 years old

Status:Now enrolling

Conducted by:Pendulum Therapeutics

Estimated enrollment:Phase 1: 30 people | Phase 2: 60 people

Design:Phase 1: Open-Label Study | Phase 2: Randomised Double-Blind, Placebo-Controlled Study

Date of completion:Estimated 2025

The study:Pendulum Therapeutics is conducting a Two-Phase Study on the Safety and Tolerance of a Novel Probiotic, GLP-1 Probiotic. The first phase will look at two different doses of the probiotic and it’s impact on food cravings and GLP-1 plasma levels. Results from the open-label phase one study will guide dose information for the Phase Two double blinded, placebo controlled study.

Goal:Evaluate the impacts of daily consumption of Pendulum GLP-1 Probiotic on measures of food cravings and plasma GLP-1 levels.

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PENDULUM GLUCOSE CONTROL

Supplementation with a next-generation synbiotic in individuals who are overweight or with obesity: a triple-blinded, randomized, controlled clinical trial

Duration:3 months

Eligibility:Adults ages 18-50, BMI: 25-40 without a diabetes diagnosis

Status:Now enrolling

Conducted by:Texas Christian University

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Estimated enrollment:60 participants

Design:Triple-blinded, randomized, placebo-controlled

Date of completion:Estimated June 2025

ClinicalTrials.gov Identifier:NCT06213480

The study:Texas Christian University is recruiting participants ages 18-50 that have a BMI between 25-40 and do not have diabetes diagnosis to join a 3-month study of Pendulum Glucose Control and measures of body composition, metabolic health, mood and eating behavior.

Goal:Evaluate impacts of daily consumption of Pendulum Glucose Control on measures of body composition, metabolic health, mood, and food behavior.

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PENDULUM GLUCOSE CONTROL

A Randomized, Double-Blind, Placebo-Controlled Study of Probiotics As Adjuvant Therapy for Bipolar Depression: A Proof-of-Concept Trial

Duration:12 weeks

Eligibility:Adults with a medical diagnosis of bipolar disease (type I or II) receiving approved treatments for bipolar depression for at least 4 weeks

Status:Now enrolling

Conducted by:University of São Paulo, Brazil (FMSUP)

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Estimated enrollment:84 participants

Design:Randomized, double-blind, placebo-controlled trial

Date of completion:Estimated 2025

ClinicalTrials.gov Identifier:NCT06213480

The study:University of São Paulo Bipolar Research Program is recruiting adults with bipolar (type I & II) presenting with subclinical depressive symptoms or a major depressive episode to participate in an outpatient randomized, double-blind, placebo-controlled trial that will last 12 weeks.

Goal:In a proof-of-concept study, evaluate the antidepressant efficacy of adjunctive administration of probiotics in participants with bipolar depression and evaluate potential inflammatory and metabolic markers associated with response to treatment.

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Akkermanisa and akkermansia 500 pro

Detection of Akkermansia muciniphila utilizing serial longitudinal samples with the BiomeSense GutLab^TM: an open-label proof of concept study

Duration:4 months

Eligibility:Adults, ages 18-75, and in general good health,
local to the San Francisco Bay Area or Chicago, IL

Status:Active, Fully Enrolled

Conducted by:Pendulum Therapeutics, BiomeSense

Press release

Estimated enrollment:10 participants + household controls

Design:Open-label

Date of completion:Estimated 2025

The study:Pendulum Therapeutics in partnership with BiomeSense are conducting a 4-month study of Pendulum Akkermansia measuring the serial longitudinal detection of the probiotic strain using BiomeSense GutLab^TM technology.

Goal:Evaluate serial longitudinal detection of Akkermansia and Akkermansia 500 PRO in stool samples of healthy individuals over an 8-week supplementation period.

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PENDULUM GLUCOSE CONTROL

OsteoPreP Study: Evaluating how Pendulum probiotics can support bone health in early postmenopausal women

Duration:12 months

Eligibility:Postmenopausal women, 40-65 years

Status:Active, Fully Enrolled

Conducted by:Australian Catholic University, Pendulum Therapeutics

Study details

Estimated enrollment:160 participants

Design:Double-blinded, randomized, placebo controlled

Date of completion:Estimated May 2025

ClinicalTrials.gov Identifier:NCT05348694

The study:Studies indicate a potential link between the gut microbiome and bone health. Australian Catholic University is recruiting female participants within 1 to 4 years of their final menses to join this 12-month study of Pendulum Glucose Control and bone health.

Goal:To measure the impacts of long-term probiotic supplementation in early postmenopausal women on bone, muscle and metabolic health.

Press Release: Researchers look at whether probiotics can slow osteoporosis in early menopause

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PENDULUM GLUCOSE CONTROL

Evaluating the safety and metabolic effects of Pendulum probiotics on glucose control associated with Type 2 diabetes

Duration:3 months

Eligibility:Type 2 diabetes, metformin, 18-75 years

Status:Completed

Conducted by:Pendulum Therapeutics

Estimated enrollment:76 participants

Design:Double-blinded, randomized, placebo controlled

Date of completion:September 2018

ClinicalTrials.gov Identifier:NCT03893422

The study:12-week double-blind, randomized placebo-controlled, proof of concept study, evaluating the safety and metabolic effects of Pendulum probiotics in the overall dietary management of Type 2 diabetes.

Goal:To evaluate the safety and metabolic effects of Pendulum probiotics on glucose control associated with Type 2 diabetes.

Results:Study participants that were administered Pendulum Glucose Control had statistically and clinically significant improvements. In individuals with Type 2 diabetes on Metformin, A1c levels were reduced by 0.6% and postprandial glucose spikes (Area Under the Curve or AUC) were reduced by 33%, as compared to placebo. Pendulum Glucose Control was safe and well-tolerated by study participants.

Press Release: First-Ever Medical Probiotic That Provides The Dietary Management Of A1C And Blood Glucose Levels

Scientific Publication: BMJ Open Diabetes Research & Care

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PENDULUM GLUCOSE CONTROL

Proof of concept study, evaluating Pendulum probiotics use in conjunction with continuous glucose monitoring smartphone app measurements

Duration:6 weeks

Eligibility:18-75 years

Status:Completed

Conducted by:Pendulum Therapeutics

Estimated enrollment:6 participants

Design:Double-blinded, randomized, placebo controlled, cross-over proof of concept study

Date of completion:June 2018

ClinicalTrials.gov Identifier:NCT04424888

The study:Self-administered meal-tolerance tests conducted to assess the impact of Pendulum Glucose Control on glucose levels through continuous glucose monitoring smart phone app measurements.

Goal:Proof-of-concept study to investigate the potential of collecting robust, real-time clinical study measures of glucose levels without clinic visits.

Results:Participants reported general satisfaction with sensor management, Pendulum Glucose Control, and the smartphone app. Despite a lack of sufficient power to achieve statistical significance, meaningful changes in the postprandial glucose response in real-world settings were detected, meriting larger studies in the future.

Press Release: Continuous Glucose Monitors Could Modernize Clinical Trials with Remote Data Collection

Scientific Publication: JMIR Formative Research

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We’re making microbiome history

We’re making microbiome history

Scientific research is our foundation

Scientific research is our foundation

Participate in breakthrough research

Clinical Trials

A Two-Phase Study on the Safety and Tolerance of a Novel Probiotic in Healthy Adults: Open-Label and Double-Blind, Placebo-Controlled Study

Supplementation with a next-generation synbiotic in individuals who are overweight or with obesity: a triple-blinded, randomized, controlled clinical trial

A Randomized, Double-Blind, Placebo-Controlled Study of Probiotics As Adjuvant Therapy for Bipolar Depression: A Proof-of-Concept Trial

Detection of Akkermansia muciniphila utilizing serial longitudinal samples with the BiomeSense GutLab^TM: an open-label proof of concept study

OsteoPreP Study: Evaluating how Pendulum probiotics can support bone health in early postmenopausal women

Evaluating the safety and metabolic effects of Pendulum probiotics on glucose control associated with Type 2 diabetes

Proof of concept study, evaluating Pendulum probiotics use in conjunction with continuous glucose monitoring smartphone app measurements

Become a microbiome pioneer

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We’re making microbiome history

We’re making microbiome history

Scientific research is our foundation

Scientific research is our foundation

Participate in breakthrough research

Clinical Trials

A Two-Phase Study on the Safety and Tolerance of a Novel Probiotic in Healthy Adults: Open-Label and Double-Blind, Placebo-Controlled Study

Supplementation with a next-generation synbiotic in individuals who are overweight or with obesity: a triple-blinded, randomized, controlled clinical trial

A Randomized, Double-Blind, Placebo-Controlled Study of Probiotics As Adjuvant Therapy for Bipolar Depression: A Proof-of-Concept Trial

Detection of Akkermansia muciniphila utilizing serial longitudinal samples with the BiomeSense GutLabTM: an open-label proof of concept study

OsteoPreP Study: Evaluating how Pendulum probiotics can support bone health in early postmenopausal women

Evaluating the safety and metabolic effects of Pendulum probiotics on glucose control associated with Type 2 diabetes

Proof of concept study, evaluating Pendulum probiotics use in conjunction with continuous glucose monitoring smartphone app measurements

Become a microbiome pioneer

Detection of Akkermansia muciniphila utilizing serial longitudinal samples with the BiomeSense GutLab^TM: an open-label proof of concept study